non volatile anesthesia (9). DROPERIDOL

DROPERIDOL
MOA antagonis reseptor dopamine

• mengganggu transmisi serotonin, NE, GABA
• tranquilizer, antiemetic
• blok  α-adrenergik 

STRUCTURE mirip haloperidol

FK 

A IM/IV

D rapid distribution phase, but sedative effect delayed by HIGH MOLECULAR WEIGHT & EXTENSIVE PROTEIN BINDING

B Liver

E Urine

Effect 
CV 

• blok  α-adrenergik :
• turunkan aBP karena periferal vasodilatation, jangan pada pasien hipovolemik
• antiaritmia efek
• QT interval memanjang, Torsaded de pointes
• Katekolamin release : jangan digunakan pada pasien feokromositoma

RESP

• TIDAK mendepresi pernapasan
• stimulasi hipoxic ventilatory drive

CEREBRAL 

• turunkan CBF, ICP : serebral vasoconstriction
• TIDAK MENURUNKAN CMRO2
• poten antiemetic
• may presipitasi EPSE
• AVOID : Parkinson, restless leg syndrome, movement disorder
• dysphoria
• tdk ANALGETIK, tdk amnesia / unconsious pada dosis biasa
• kombinasi fentanil dengan droperidol (Innovar) -> analgesia, immobility, variable amnesia (neuroleptanalgesia)
• + NO2 or hipnotik agent -> unconscious & general anesthesia similar dissosiatif state induce by ketamine

DRUG INTERACTION (DI)

• Antagonis efek levodopa : presipitasi parkinson, renal effect of dopamine are encountered by droperidol
• antagonis sentral α-adrenergik action of clonidine & precipitate rebound hypertension
• turunkan kardio efek dari ketamine